everyminute.org supports innovative research that will profoundly transform the diagnosis, treatment, and prevention of mental disorders, paving the way for a cure. The need for transformative, innovative research is urgent; each year, as many as 57 million Americans meet criteria for some mental disorder, with roughly 12 million reporting symptoms so severe as to cause significant disability and interference with everyday living. Similarly, the economic costs of mental disorders are estimated at over $317 billion, with most due to the loss of economic productivity as a result of the illnesses. We know that mental disorders can also be fatal. Each year more Americans die from suicide than from homicide. In sum, these are real disorders requiring life-saving treatments.